Hydrochloric Acid → HCID 21449493, compound

Participants

Reaction Steps

A stirred mixture of 2-cyclopentyl-2-methyl-6,7-dichloroindan-1,5-diol (α isomer) (1.9 g., 0.0063 mole), potassium carbonate (1.3 g., 0.0095 mole) and ethylbromoacetate (1.5 g. 0.0095 mole) in dimethylformamide (20 ml.) is warmed at 55°-60° C. under nitrogen for 2 hours, then treated with water (20 ml.) and 10N sodium hydroxide (1.9 ml.) and heated on a steam bath for one-half hour. The reaction mixture is poured into ice water (300 ml.) and while ice cold, 1N HCl is added dropwise with stirring to give 1.36 g. of (1-hydroxy-2-cyclopentyl-2-methyl-6,7-dichloro-5-indanyloxy)acetic acid (α isomer) which melts at 129°-131° C. after crystallization from benzene : hexane, 1:1.

Provenance & Evidence