HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 2-Bromo-2',3'-dichloro-4'-methoxyisobutyrophenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 2',3'-Dichloro-4'-methoxyisobutyrophenone | HCID 12395550 | — |
| Reactant | Sodium Bisulfite | HCID 23665763 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-Bromo-2',3'-dichloro-4'-methoxyisobutyrophenone | HCID 12395604 | — |
Reaction Steps
A stirred solution of 2',3'-dichloro-4'methoxyisobutyrophenone (45 g., 0.183 mole) in acetic acid (150 ml.) is treated during 1/2 hour with bromine (30 g., 0.187 mole). The reaction mixture is stirred 10 minutes, then poured into ice water (600 ml.) containing sodium bisulfite (2 g.). The 2-bromo-2'-3'-dichloro-4'-methoxyisobutyrophenone which separates (48 g.) melts at 72°-73° C. after recrystallization from hexane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04012524 |
| Source dataset | uspto-grants-1977_03 |
| ORD ID | ord-12e688d281ce4f70a40f06af7c32c271 |
| Source note | uspto-grants-1977_03 |