HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl bromoacetate → (1-Hydroxy-2,2-dimethyl-6,7-dichloro-5-indanyloxy)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2,2-Dimethyl-6,7-dichloro-1,5-indanediol | HCID 21449488 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (1-Hydroxy-2,2-dimethyl-6,7-dichloro-5-indanyloxy)acetic acid | HCID 21449496 | — |
Reaction Steps
(1-Hydroxy-2,2-dimethyl-6,7-dichloro-5-indanyloxy)acetic acid is prepared following substantially the same procedure described in Example 4, Step F, using the following substances: 2,2-dimethyl-6,7-dichloro-1,5-indanediol (3.7 g., 0.015 mole); potassium carbonate (3.6 g.); ethyl bromoacetate (3.1 ml.); and dimethylformamide (35 ml.), and hydrolyzing the resultant ester with aqueous sodium hydroxide in accordance with Example 4, Step F, gives (1-hydroxy-2,2-dimethyl-6,7-dichloro-5-indanyloxy)acetic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04012524 |
| Source dataset | uspto-grants-1977_03 |
| ORD ID | ord-ae9e6aa255f0400485125dbc8ee71b52 |
| Source note | uspto-grants-1977_03 |