Hydrochloric Acid → HCID 21449501, compound

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Reaction Steps

2-Cyclopentyl-2-methyl-6,7-dichloroindan-1,5-diol (Example 5, Step C) (15.6 g., 0.05 mole) is dissolved in a 10% sodium hydroxide solution (50 ml.). The solution is heated to reflux and beta-propiolactone, (36.0 g., 0.5 mole) is added at such as to keep the reaction mixture refluxing. The reaction mixture is kept basic by the addition of 10% sodium hydroxide. The reaction mixture is cooled and acidified with dilute hydrochloric acid. The product is extracted with ether and extracted from the other solution with a 5% solution of sodium bicarbonate. Acidification affords the desired product.

Provenance & Evidence