Ethyl bromoacetate → HCID 12395614, compound

Participants

Reaction Steps

(1-Oxo-2-ethyl-3-phenyl-6,7-dichloro-5-indanyloxy)acetic acid is prepared following substantially the same procedure described in Example 4, Step F, using the following substances: 2-ethyl-3-phenyl-5-hydroxy-6,7-dichloro-1-indanone (16.6 g., 0.0518 mole); potassium carbonate (14.4 g., 0.104 mole); ethyl bromoacetate (17.3 g., 0.104 mole); and dimethylformamide (80 ml.); and hydrolyzing the resultant ester in accordance with Example 4, Step F, there is obtained 14.4. g. (74%) of (1-oxo-2-ethyl-3-phenyl-6,7-dichloro-5-indanyloxy)acetic acid which after recrystallization from acetic acid melts at 203°-206° C.

Provenance & Evidence