HCID 21449375, compound → HCID 21449367, compound

Participants

Reaction Steps

A solution of 7-chloro-4-(2-methylindolin-1-yl)quinoline (17g.) in diphenyl ether (50ml.) containing 10% w/w palladium on charcoal catalyst (6.5g.) was heated under reflux for 3 hours. The mixture was cooled and filtered, and the solid residue was extracted with hot chloroform (3 × 50ml.; ca 60° C.). The chloroform was evaporated in vacuo from the extract. The residue was chromatographed on a column of chromatographic silica gel (column dimensions: 20 × 3.5cm.) using a 1:3 v/v mixture of diethyl ether and petroleum ether (b.p. 40°-60° C.) as eluant. The solvents were evaporated in vacuo from the eluate to give 4-(2-methylindol-1-yl)quinoline, m.p. 78°-80° C.

Provenance & Evidence