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Acetaldehyde → 1-[2-(diethylamino)ethyl]-8-chloro-6-phenyl-4H-s-triazolo-[4,3-a][1,4]benzodiazepine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetaldehyde | HCID 177 | — |
| 反応物 | Ethylenediamine | HCID 3301 | — |
| 反応物 | Sodium cyanoborohydride | HCID 5003444 | — |
| 反応物 | 1-(2-aminoethyl)-8-chloro-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine | HCID 12612403 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 1-[2-(diethylamino)ethyl]-8-chloro-6-phenyl-4H-s-triazolo-[4,3-a][1,4]benzodiazepine | HCID 12612440 | — |
反応手順
In the manner given in Example 22, a mixture of 1-(2-aminoethyl)-8-chloro-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine, acetaldehyde and acetic acid in acetonitrile is treated with sodium cyanoborohydride and the resulting boron complex is warmed with aqueous ethylenediamine to give 1-[2-(diethylamino)ethyl]-8-chloro-6-phenyl-4H-s-triazolo-[4,3-a][1,4]benzodiazepine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04012413 |
| 出典データセット | uspto-grants-1977_03 |
| ORD ID | ord-70b38c05c52f41c985c03e8ba84dceb2 |
| 出典メモ | uspto-grants-1977_03 |