HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1'-Carbonyldiimidazole → 3-phthalimidobutyric acid 2-[7-chloro-5-(o-fluorophenyl)-3H-1,4-benzodiazepin-2yl]hydrazide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 7-chloro-2-hydrazino-5-(o-fluorophenyl)-3H-1,4-benzodiazepine | HCID 12390887 | — |
| Reactant | 3-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoic acid | HCID 12612390 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-phthalimidobutyric acid 2-[7-chloro-5-(o-fluorophenyl)-3H-1,4-benzodiazepin-2yl]hydrazide | HCID 54408602 | — |
Reaction Steps
In the manner given in Example 20, 3-phthalimidobutyric acid and carbonyldiimidazol are reacted in tetrahydrofuran. To this mixture is added 7-chloro-2-hydrazino-5-(o-fluorophenyl)-3H-1,4-benzodiazepine to give 3-phthalimidobutyric acid 2-[7-chloro-5-(o-fluorophenyl)-3H-1,4-benzodiazepin-2yl]hydrazide which is warmed with acetic acid to give N-[2-[8-chloro-6-(o-fluorophenyl)-4H-s-triazolo-[4,3-a][1,4]benzodiazepin-1-yl]propyl]phthalimide
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04012413 |
| Source dataset | uspto-grants-1977_03 |
| ORD ID | ord-d45c31ec60584e63ac2bee3614138e81 |
| Source note | uspto-grants-1977_03 |