1,1'-Carbonyldiimidazole → 3-phthalimidovaleric acid, 2-(7-chloro-5-phenyl-3H-1,4-benzodiazepin-2-yl)hydrazide

Participants

Reaction Steps

In the manner given in Example 20, 3-phthalimidovaleric acid and carbonyldiimidazole are allowed to react in tetrahydrofuran. To this mixture is added 7-chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine to give 3-phthalimidovaleric acid, 2-(7-chloro-5-phenyl-3H-1,4-benzodiazepin-2-yl)hydrazide which is warmed with acetic acid to give N-[2-(8-chloro-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepin-1-yl)butyl]phthalimide

Provenance & Evidence