Itaconic acid → HCID 22051563, compound

Participants

Reaction Conditions

Reaction Steps

229 g (1 mole) of 3,5-bis-(trifluoromethyl)-aniline and 136.5 g (1.05 moles) of itaconic acid are stirred in 55 ml of water during 24 hours at 200° C in an autoclave. The reaction mixture is subsequently cooled to 20° C and 2 liters of cold water are added. Two liters of water are then evaporated, and the reaction mixture is again cooled to 20° C. The crystals that have precipitated are filtered off, dried, dissolved in 400 ml of diethyl ether and precipitated with 600 ml of n-hexane. There is obtained 242 g (71% of theory) of 1-(3,5-bis-trifluoromethylphenyl)-2-oxo-pyrrolidine-4-carboxylic acid; m.p. 108°-9° C.

Provenance & Evidence