Benzene, 1,1′-[1-(chloromethyl)-1,2-ethenediyl]bis- → HCID 53881489, compound

HRID 597142Notes

Reaction equation

HRID 597142 reaction equation
[C:1]1([C:7](=[CH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:8]Cl)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C[Si]([N:21]([Si](C)(C)C)[C:22]1[CH:27]=[CH:26][NH:25][C:24](=[O:28])[N:23]=1)(C)C>C1C=CC=CC=1>[C:1]1([C:7](=[CH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:8][N:25]2[CH:26]=[CH:27][C:22]([NH2:21])=[N:23][C:24]2=[O:28])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 54379748Benzene, 1,1′-[1-(chloromethyl)-1,2-ethenediyl]bis-HCID 178504300HCID 178504300, compound

Product 1

HCID 53881489HCID 53881489, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A solution of 10 parts of 2,3-diphenylallyl chloride in 43.9 parts of benzene is treated with 20 parts of bis-trimethylsilylcytosine under a nitrogen atmosphere and then the reaction container is sealed and maintained at a temperature of 65° for 120 hours. The solid which forms is collected by filtration, washed with benzene and recrystallized from a 1:1 acetic acid-water mixture to yield 1-(2,3 -diphenylallyl)-4-amino-2-oxo-1,2-dihydro-pyrimidine. That product displays nuclear magnetic resonance maxima at about 293, 405, 425, 437, 453 and 461 Hertz and is represented structurally by the following formula ##STR8##

Workup

  1. customthe reaction container is sealed
  2. temperaturemaintained at a temperature of 65° for 120 hours
  3. filtrationThe solid which forms is collected by filtration
  4. washwashed with benzene
  5. customrecrystallized from a 1:1 acetic acid-water mixture

Sources & evidence

ORD record
ord-1e7ab8d6a2804717a347540eade4fc4a
Source dataset
uspto-grants-1977_03
Patent number
US04013643

Reaction notes

Loading…