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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 597175Generated: October 30, 2026

1-Cyclopropylpiperidin-4-one → 8-Cyclopropyl-1,2,7,8,9,10-hexahydropyrido[3',4':4,5]pyrrolo[1,2,3-de][1,4]benzoxazine hydrochloride

https://huagongshe.com/reaction/597175

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Cyclopropylpiperidin-4-oneHCID 16227629—
Reactant2H-benzo[b][1,4]oxazin-4(3H)-amine hydrochlorideHCID 22488985—
Product8-Cyclopropyl-1,2,7,8,9,10-hexahydropyrido[3',4':4,5]pyrrolo[1,2,3-de][1,4]benzoxazine hydrochlorideHCID 20304775—

Reaction Steps

4-Amino-3,4-dihydro-2H-1,4-benzoxazine hydrochloride is reacted with 1-cyclopropyl-4-piperidone according to the procedure of Example 110 to yield the title compound, m.p. 232°-233° .

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04013652
Source datasetuspto-grants-1977_03
ORD IDord-c83440ad900b457dba00daab5b046f91
Source noteuspto-grants-1977_03