HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminophenol → 2-Phenyl-3,4-dihydro-2H-1,4-benzoxazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminophenol | HCID 5801 | — |
| Reactant | Acetyl chloride, 2-(2-chlorophenyl)- | HCID 182669 | — |
| Reactant | 3,4-Dihydro-2H-1,4-benzoxazine | HCID 585096 | — |
| Product | 2-Phenyl-3,4-dihydro-2H-1,4-benzoxazine | HCID 13790491 | — |
Reaction Steps
By a procedure similar to that described for the synthesis of 3,4-dihydro-2H-1,4-benzoxazine (Example 142), o-aminophenol and 2-chlorophenylacetyl chloride produces 3,4-dihydro-2-phenyl-2H-1,4-benzoxazine, m.p. 113°-116° which, according to the reaction scheme of Example 110 is converted to the title compound, m.p. 311°-313°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04013652 |
| Source dataset | uspto-grants-1977_03 |
| ORD ID | ord-c8f841f2896f4822ae83fc179f954723 |
| Source note | uspto-grants-1977_03 |