反应详情

89.2 g of 5-benzyloxy-2-formyl-1,2,3,4-tetrahydro-6-methoxy-isoquinoline are dissolved in 450 ml of glacial acetic acid and hydrogenated at room temperature and normal pressure in the presence of 4.5 g of 5 percent palladium black. After conclusion of hydrogen absorption, the reaction mixture is separated from the catalyst by filtration and evaporated to dryness under reduced pressure. Recrystallization of the residue from ethanol gives 57.2 g of 2-formyl-1,2,3,4-tetrahydro-5-hydroxy-6-methoxy-isoquinoline. m.p. = 172.5° - 173.5° C.

1. customAfter conclusion of hydrogen absorption
2. customthe reaction mixture is separated from the catalyst by filtration
3. customevaporated to dryness under reduced pressure
4. customRecrystallization of the residue from ethanol