2-Aminomethyl-1-ethylpyrrolidine → 2,5-bis(2,2,2-trifluoroethoxy)-N-[(1-ethyl-2-pyrrolidyl)methyl]benzamide

HRID 597224노트

반응식

HRID 597224 반응식
[CH2:1]([N:3]1[CH2:7][CH2:6][CH2:5][CH:4]1[CH2:8][NH2:9])[CH3:2].[F:10][C:11]([F:35])([F:34])[CH2:12][O:13][C:14]1[CH:27]=[CH:26][C:25]([O:28][CH2:29][C:30]([F:33])([F:32])[F:31])=[CH:24][C:15]=1[C:16](OCC(F)(F)F)=[O:17]>>[F:10][C:11]([F:34])([F:35])[CH2:12][O:13][C:14]1[CH:27]=[CH:26][C:25]([O:28][CH2:29][C:30]([F:33])([F:32])[F:31])=[CH:24][C:15]=1[C:16]([NH:9][CH2:8][CH:4]1[CH2:5][CH2:6][CH2:7][N:3]1[CH2:1][CH3:2])=[O:17]

참가 물질

3

반응물 2

HCID 1172952-Aminomethyl-1-ethylpyrrolidineHCID 112810142,2,2-Trifluoroethyl 2,5-bis(2,2,2-trifluoroethoxy)benzoate

생성물 1

HCID 541427402,5-bis(2,2,2-trifluoroethoxy)-N-[(1-ethyl-2-pyrrolidyl)methyl]benzamide

실험 절차

Using the synthetic method illustrated in Example 23, 1-ethyl-2-aminomethyl pyrrolidine and 2,2,2-trifluoroethyl 2,5-bis(2,2,2-trifluoroethoxy)benzoate are reacted to provide a white solid, 2,5-bis(2,2,2-trifluoroethoxy)-N-[(1-ethyl-2-pyrrolidyl)methyl]benzamide, m.p. 78°-80° C.

후처리

  1. customare reacted

출처 및 근거

ORD 기록
ord-ed1c837ddfe04296a6eb2bf2afabceab
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04013670

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