Sulfuric Acid → HCID 68122489, compound

HRID 597245Notes

Reaction equation

HRID 597245 reaction equation
[S:1](=[O:5])(=[O:4])([OH:3])[OH:2].[CH:6]1([C:9]([N:11]2[CH2:20][CH2:19][C:18]3[C:13](=[CH:14][C:15]([O:23][CH3:24])=[C:16]([O:21][CH3:22])[CH:17]=3)/[C:12]/2=[CH:25]/[C:26]2[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[C:28]([O:34][CH3:35])[CH:27]=2)=O)[CH2:8][CH2:7]1>O>[S:1]([O-:5])([OH:4])(=[O:3])=[O:2].[CH:6]1([C:9]2[C:13]3[CH:14]=[C:15]([O:23][CH3:24])[C:16]([O:21][CH3:22])=[CH:17][C:18]=3[CH:19]=[C:20]3[N+:11]=2[CH2:12][CH2:25][C:26]2[CH:27]=[C:28]([O:34][CH3:35])[C:29]([O:32][CH3:33])=[CH:30][C:31]=23)[CH2:8][CH2:7]1

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 68123014HCID 68123014, compound

Product 1

HCID 68122489HCID 68122489, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 10 parts of concentrated sulfuric acid, with vigorous agitation at 0°, is slowly added 1 part of (Z)-2-cyclopropylcarbonyl-1,2,3,4-tetrahydro-6,7-dimethoxy1-[(3,4-dimethoxyphenyl)methylene]isoquinoline. When the addition is complete, 90 parts of water is mixed in; and the yellow precipitate which forms is isolated by filtration and recrystallized from water, affording 8-cyclopropyl5,6-dihydro-2,3,10,11-tetramethoxydibenzo[a,g]quinolizinium hydrogen sulfate melting above 300°.

Workup

  1. additionWhen the addition
  2. customand the yellow precipitate which forms is isolated by filtration
  3. customrecrystallized from water

Sources & evidence

ORD record
ord-fee5ff8f90004727ae29392e91b74d35
Source dataset
uspto-grants-1977_03
Patent number
US04013666

Reaction notes

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