Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 597253Generated: October 30, 2026

1,2,3,4-Tetrahydro-8,9-dimethoxy-3-(2-morpholinoethyl)5H-[1]benzopyrano-[3,4-c]pyridin-5-one → 1,2,3,4-tetrahydro-8,9-dihydroxy-3-(2-morpholinoethyl)-5H-[1]benzopyrano[3,4-c]pyridin-5-one

https://huagongshe.com/reaction/597253

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,2,3,4-Tetrahydro-8,9-dimethoxy-3-(2-morpholinoethyl)5H-[1]benzopyrano-[3,4-c]pyridin-5-oneHCID 21447171—
SolventHydrogen BromideHCID 260—
Product1,2,3,4-tetrahydro-8,9-dihydroxy-3-(2-morpholinoethyl)-5H-[1]benzopyrano[3,4-c]pyridin-5-oneHCID 2144716768.3%

Reaction Steps

A solution of 8.7 g of 1,2,3,4-tetrahydro-8,9-dimethoxy-3-(2-morpholinoethyl)-5H[1]benzopyrano[3,4-c]-pyridin-5-one in 60 cc of 48% HBr was refluxed for 17 hr then cooled. Crystallization of precipitate from water afforded 5.5 g of product; mp 299°-302° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04013671
Source datasetuspto-grants-1977_03
ORD IDord-8d1efc679d80405c97304a58e3afc00b
Source noteuspto-grants-1977_03