Water → HCID 21447336, compound

Participants

Reaction Steps

5g of 2-(4-cyclohexyl-2-hydroxyphenyl)- propionic acid are heated at reflux in a water separator for 2 hours in the presence of 50 mg of p-toluenesulphonic acid in 200 cc of toluene. The solution is concentrated by evaporation and the residue is chromatographed on 500 g of silica gel. Elution with methylene chloride yields pure 6-cyclohexyl-2,3-dihydro-3-methylbenzofuran-2-one having an M.P. of 87-89° after crystallization from petroleum ether.

Provenance & Evidence