Ethanol → HCID 70608017, compound

HRID 597288Notes

Reaction equation

HRID 597288 reaction equation
[C:1]1([C:7]2[CH:15]=[C:11]3[CH:12]=[CH:13][CH:14]=[C:10]3[O:9][C:8]=2[CH2:16][C:17]([OH:19])=[O:18])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(=O)(=O)(O)O.[CH2:25](O)[CH3:26]>>[C:1]1([C:7]2[CH:15]=[C:11]3[CH:12]=[CH:13][CH:14]=[C:10]3[O:9][C:8]=2[CH2:16][C:17]([O:19][CH2:25][CH3:26])=[O:18])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 70609976HCID 70609976, compound

Product 1

HCID 70608017HCID 70608017, compound

Procedure

A solution of 40 g., of 3-phenyl-7-benzofuranacetic acid in 400 ml. of ethanol and 40 ml. of sulfuric acid is heated under reflux for four hours. The solution is partially concentrated under reduced pressure, poured onto ice and extracted with ether. The ether is washed, dried and concentrated and the residue distilled to give ethyl 3-phenyl-7-benzofuranacetate, b.p. 187°-189°/0.12 mm.

Workup

  1. temperatureunder reflux for four hours
  2. concentrationThe solution is partially concentrated under reduced pressure
  3. additionpoured onto ice
  4. extractionextracted with ether
  5. washThe ether is washed
  6. customdried
  7. concentrationconcentrated
  8. distillationthe residue distilled

Sources & evidence

ORD record
ord-a4dd0cd86dc3449cbfa927c2b16c602b
Source dataset
uspto-grants-1977_03
Patent number
US04013692

Reaction notes

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