2-Bromophenol → HCID 21447344, compound

HRID 597292Notes

Reaction equation

HRID 597292 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].[Cl:9][C:10]1[CH:11]=[C:12]([C:17]2C=C3C=CC=C3O[C:18]=2CC(O)=O)[CH:13]=[CH:14][C:15]=1[Cl:16]>>[Br:1][C:2]1[C:3]2[O:8][CH:18]=[C:17]([C:12]3[CH:13]=[CH:14][C:15]([Cl:16])=[C:10]([Cl:9])[CH:11]=3)[C:4]=2[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 72442-BromophenolHCID 70637816HCID 70637816, compound

Product 1

HCID 21447344HCID 21447344, compound

Procedure

Starting with 2-bromophenol and alpha-bromo-3,4-dichloroacetophenone and using Process A as described in Examples 1 and 2, the compound 7-bromo-3-(3,4-dichlorophenyl)benzofuran is prepared. Using Process F as described in Examples 6 to 9, this compound is converted to 3-(3,4-dichlorophenyl)-7-benzofuranacetic acid, m.p. 158.5°-160° C.

Sources & evidence

ORD record
ord-904e0643e71e436980f4388f1fc3bc01
Source dataset
uspto-grants-1977_03
Patent number
US04013692

Reaction notes

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