Ethyl 4-bromobutyrate → 4-[p-(1-Cycloheptenyl)-phenoxy]-butyric acid ethyl ester

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Reaction Steps

Analogously to the process described in Example 1, using 13.2 g of p-(1-cycloheptenyl)-phenol and 21.1 g of 4-bromobutyric acid ethyl ester as starting material gives crude 4-[p-(1-cycloheptenyl)-phenoxy]-butyric acid ethyl ester of boiling point 160° C at 0.03 mm Hg, after chromatography on silica gel with methylene chloride as the eluant and subsequent fractional distillation in a high vacuum.

Provenance & Evidence