Benzene → HCID 13243693, compound

Participants

Reaction Steps

A mixture of a solution of 0.94 g. of the thus obtained di-(chloroacetyl) derivative of 3-amino-6-bromo-4-hydroxy-4 -(2-pyridyl)-3,4-dihydroquinazoline in 19 ml. of benzene and 0.4 g. of monochloro acetic acid is refluxed for 30 minutes. Then, the benzene layer is washed with water. After evaporation of benzene under reduced pressure, the residue is washed with a mixture of methanol and isopropyl ether to give 4-[4-bromo-2-(2-pyridinecarbonyl)phenyl]-3-chloromethyl-4H-1,2,4-triazole as crystals. Recrystallization from ethyl acetate gives colorless crystals melting at 146° to 147° C.

Provenance & Evidence