Thionyl Chloride → HCID 13243694, compound

Participants

Reaction Steps

According to the similar procedure as described in Example 4, the reaction product of 8-bromo-1-ethyl-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine and 6 N hydrochloric acid-sodium nitrite is chlorinated with thionyl chloride to give 4-[4-bromo-2-(2-pyridinecarbonyl)-phenyl]-3-chloromethyl-5-ethyl-4H-1,2,4-triazole as crystals. Recrystallization from acetone gives pale yellow prisms melting at 199° to 201° C. (decomposition).

Provenance & Evidence