反应详情

A solution of 15.9 g (0.09 mol) of 3-trifluoromethylthiophenol and 3.8 g (0.095 mol) of sodium hydroxide pellets in 100 ml of water is heated at 65°-70° C and 8.5 g (0.095 mol) of β-chloropropionitrile are added dropwise whilst stirring. The mixture is heated for a quarter of an hour to the reflux temperature and is then cooled and extracted with ether, and the extract is washed with water and dried with magnesium sulphate. This gives 3-(3-trifluoromethylphenylthio)-propionitrile, which is not isolated.

1. temperatureThe mixture is heated for a quarter of an hour to the reflux temperature
2. temperatureis then cooled
3. extractionextracted with ether
4. washthe extract is washed with water
5. dry with materialdried with magnesium sulphate