HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1-Bis(methylthio)-2-nitroethylene → 1-Nitro-2-[2-(2-pyridylmethylthio)ethylamino]-2-[2-((4-bromo-5-imidazolyl)methylthio)ethylamino]ethylene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1-Bis(methylthio)-2-nitroethylene | HCID 83623 | — |
| Reactant | 2-(((5-Bromo-1H-imidazol-4-yl)methyl)thio)ethanamine | HCID 12788949 | — |
| Reactant | 2-((2-Aminoethyl)thiomethyl)pyridine | HCID 12889401 | — |
| Reactant | 1-nitro-2-methylthio-2-{2-[(4-bromo-1H-imidazol-5-yl)methylthio]ethylamino}ethylene | HCID 70544030 | — |
| Product | 1-Nitro-2-[2-(2-pyridylmethylthio)ethylamino]-2-[2-((4-bromo-5-imidazolyl)methylthio)ethylamino]ethylene | HCID 70624509 | — |
Reaction Steps
When 4-bromo-5-[(2-aminoethyl)thiomethyl]imidazole (from the dihydrobromide (4.8 g)) is reacted with 1-nitro-2,2-bis-methylthioethylene (2.0 g) according to the procedure of Example 8(i) and the resultant 1-nitro-2-methylthio-2-[2-((4-bromo-5-imidazolyl)methylthio)ethylamino]ethylene reacted with 2-[(2-aminoethyl)thiomethyl]pyridine by the procedure of Example 1 (a) (ii), the title compound is produced.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04013769 |
| Source dataset | uspto-grants-1977_03 |
| ORD ID | ord-e4caf80bfcfc4a8b9cfd5df07ab74fef |
| Source note | uspto-grants-1977_03 |