1,1-Bis(methylthio)-2-nitroethylene → 1-Nitro-2-methylthio-2-[3-(2-oxazolylthio)propylamino]ethylene

HRID 597407Notes

Reaction equation

HRID 597407 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][S:5][C:6]1[O:7][CH:8]=[CH:9][N:10]=1.[N+:11]([CH:14]=[C:15](SC)[S:16][CH3:17])([O-:13])=[O:12]>>[N+:11]([CH:14]=[C:15]([S:16][CH3:17])[NH:1][CH2:2][CH2:3][CH2:4][S:5][C:6]1[O:7][CH:8]=[CH:9][N:10]=1)([O-:13])=[O:12]

Participants

3

Reactant 2

HCID 836231,1-Bis(methylthio)-2-nitroethyleneHCID 205501192-(3-Aminopropyl)thiooxazole

Product 1

HCID 705413921-Nitro-2-methylthio-2-[3-(2-oxazolylthio)propylamino]ethyleneYield 63%

Procedure

By the procedure of Example 8(i), 2-(3-aminopropylthio)oxazole (2.1 g) is reacted with 1-nitro-2,2-bis-methylthioethylene (2.0 g) to give 1-nitro-2-methylthio-2-[3-(2-oxazolylthio)propylamino]ethylene (2.1 g) which, on reaction with 2-[(2-aminoethyl)thiomethyl]-3-chloropyridine by the procedure of Example 1 (a)(ii) gives the title product (2.2 g).

Sources & evidence

ORD record
ord-0137f70711184c24a377510aa11418e8
Source dataset
uspto-grants-1977_03
Patent number
US04013769

Reaction notes

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