HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 1-Nitro-2-methylthio-2-[2-(3-isoxazolylmethylthio)ethylamino]ethylene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | 1,1-Bis(methylthio)-2-nitroethylene | HCID 83623 | — |
| Reactant | 2-((Isoxazol-3-ylmethyl)thio)ethanamine | HCID 12923417 | — |
| Product | 1-Nitro-2-methylthio-2-[2-(3-isoxazolylmethylthio)ethylamino]ethylene | HCID 70544411 | — |
Reaction Steps
By the procedure of Example 8(i), 3-[(2-aminoethyl)-thiomethyl]isoxazole (from the hydrobromide (3.7 g)) is reacted with 1-nitro-2,2-bis-methylthioethylene (3.5 g) to give 1-nitro-2-methylthio-2-[2-(3-isoxazolylmethylthio)-ethylamino]ethylene (3.6 g) which, on reaction with 2-[(2-aminoethyl)thiomethyl]-3-chloropyridine by the procedure of Example 1 (a) (ii) gives the title product (3.5 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04013769 |
| Source dataset | uspto-grants-1977_03 |
| ORD ID | ord-fa556d053d334422b33e291d5abd2fc5 |
| Source note | uspto-grants-1977_03 |