反应详情

A strong stream of dry ammonia is passed (for 15 minutes) into a solution of 16.5 g of 4-[4-(1-adamantyl)-phenoxy]-butyric acid chloride in 150 ml of absolute benzene under anhydrous conditions, whilst stirring. The product formed is now filtered off and washed with ether. Recrystallisation from a large amount of acetone yields pure 4-[4-(1-adamantyl)-phenoxy]-butyric acid amide of melting point 176°-177° C (needles).

1. custom(for 15 minutes)
2. customThe product formed
3. filtrationis now filtered off
4. washwashed with ether
5. customRecrystallisation from a large amount of acetone