反应详情

温度

30 °C

3.9 g of diketene were added to a mixture of 6.9 g of m-(n-butyl)-aniline and 70 ml of benzene and the mixture was stirred for 2 hours at 30° C. The benzene was evaporated under reduced pressure and the residue was chromatographed over silica gel. Elution with an 8-2 mixture of methylene chloride and ethyl acetate yielded 8.5 g of m-(n-butyl)-acetylacetanilide in the form of an oil with a refractive index of nD 20 = 1.5355.

1. customThe benzene was evaporated under reduced pressure
2. customthe residue was chromatographed over silica gel
3. washElution
4. additionwith an 8-2 mixture of methylene chloride and ethyl acetate