Ethylamine → 6-Chloro-N-ethyl-5-nitro-2-(trifluoromethyl)pyrimidin-4-amine

Participants

Reaction Conditions

Reaction Steps

5.25 g (0.02 mole) of 4,6 -dichloro-5-nitro-2-trifluoromethyl-pyrimidine are dissolved in 100 ml of absolute ethanol and the solution is cooled to -30° C. At this temperature 2.0 g (0.02 mole) of triethylamine as acid acceptor and 0.9 g (0.02 mole) of ethylamine are added. The mixture is stirred initially for 4 hours at -20° to -30° C and then for 6 hours at 0° C. After it has been left to stand overnight at 20° C, the reaction mixture is concentrated to dryness and the residue is taken up in water and washed with water. The ethereal phase is dried and concentrated to yield 5.3 g of 4-ethylamino-6-chloro-5-nitro-2-trifluoromethyl-pyrimidine as a pale yellow oil (nD20 : 1.4985).

Provenance & Evidence