Cyclopropylamine → HCID 21445068, compound

Participants

Reaction Steps

28.6 g (0.5 mole) of cyclopropylamine are added dropwise ar -50° C to 55.5 g (0.25 mole) of 2-ethyl-4,6-dichloro-5-nitro-pyrimidine in 1 liter of ethanol. The reaction mixture is stirred for 3 hours at room temperature and then cooled to -40° C. The crystalline precipitate that has formed is filtered off and dried. Yield: 21 g of 2-ethyl-4-chloro-5-nitro-6-cyclopropylamino-pyrimidine of m.p. 61°-62° C. A Further 22 g of 2-ethyl-4-chloro-5-nitro-6-cyclopropylamino-pyrimidine of m.p. 61°-62° C are obtained by evaporating the filtrate, suspending the residue in water, extracting with ether, drying the ethereal extracts over MgSO4 and evaporating them.

Provenance & Evidence