Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Pentanamine | HCID 12019 | — |
| Reactant | HCID 21445107 | HCID 21445107 | — |
| Product | HCID 131710700 | HCID 131710700 | — |
Reaction Steps
20.2 g (0.2 mole) of triethylamine are added to 47.2 g (0.2 mole) of 2,4-dichloro-5-nitro-6-isopropyl-pyridine in 1 liter of ethanol and 17.5 g (0.2 mole) of 3-aminopentane are added dropwise at -20° C. The reaction mixture is stirred overnight at 20° C and then concentrated. The residue is suspended in water and extracted with ether. The ethereal extracts are drid over MgSO4 and evaporated. The product is purified by adsorption chromatography on silica gel by elution with benzene to yield 48 g of 2-chloro-4-(3-pentylamino-5-nitro-6-isopropyl-pyrimidine (nD20 : 1.5478).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04014677 |
|---|
| Source dataset | uspto-grants-1977_03 |
|---|
| ORD ID | ord-c4cabf65134f4e46bd0e4cd78c0d77de |
|---|
| Source note | uspto-grants-1977_03 |
|---|
