Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methylmercaptan sodium | HCID 45051789 | — |
| Reactant | HCID 54438131 | HCID 54438131 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 53652465 | HCID 53652465 | 95.3% |
Reaction Steps
A solution of 14.4 g (50 m-moles) of 2-chloro-4-(3-pentylamino)-5-nitro-6-isopropyl-pyrimidine in 50 ml of ether is added dropwise to a suspension of 3.5 g (50 m-moles) of sodium methylmercaptan in 50 ml of dimethyl sulphoxide. The reaction mixture is stirred for 1 hour at 20° C, then poured into 0.5 liter of water and extracted with ether. The ethereal extracts are dried over MgSO4, dried and evaporated to yield 14 g of 2-methylthio-4-(3-pentylamino)-5-nitro-6-isopropyl-pyrimidine as an oil (nD20 : 1.5757).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04014677 |
|---|
| Source dataset | uspto-grants-1977_03 |
|---|
| ORD ID | ord-371984034ea7445fb998f8360746fb65 |
|---|
| Source note | uspto-grants-1977_03 |
|---|
