HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 597472Generated: October 30, 2026
Sodium → 2-Methylthio-4-isopropylamino-5-nitro-6-allyloxypyrimidine
https://huagongshe.com/reaction/597472
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 2-Methylthio-4-isopropylamino-5-nitro-6-chloro-pyrimidine | HCID 21445103 | — |
| Reactant | Sodium prop-2-enolate | HCID 23669913 | — |
| Solvent | Allyl Alcohol | HCID 7858 | — |
| Product | 2-Methylthio-4-isopropylamino-5-nitro-6-allyloxypyrimidine | HCID 21445070 | — |
Reaction Steps
A solution of sodium allyl alcoholate (prepared from 1.2 g (50 m-moles of sodium in 50 ml of allyl alcohol) is added to 13.2 g (50 m-moles) of 2-methylthio-4-isopropylamino-5-nitro-6-chloro-pyrimidine and the mixture is stirred overnight at 20° C. The allyl alcohol is evaporated off, the residue is suspended in water and extracted with ether. The ethereal extracts are dried over MgSO4 and concentrated to yield 15 g of 2-methylthio-4-isopropylamino-5-nitro-6-allyloxypyrimidine of m.p. 51°-54° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04014677 |
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| Source dataset | uspto-grants-1977_03 |
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| ORD ID | ord-0439755111a24939a6721c56e289006e |
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| Source note | uspto-grants-1977_03 |
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