反应详情

A solution of N-isopropylaniline (30 g) in dry benzene (150 ml) was cooled to 5°-10° C and phosgene passed therethrough slowly for 11/2 hours. The mixture was refluxed for 1 hour to remove excess phosgene, cooled and the amine hydrochloride was filtered off. The solvent was evaporated and the residue recrystallised from benzene-petroleum ether 1:1, giving 21.6 g, m.p. 89°-90° C.

1. custom2 hours
2. temperatureThe mixture was refluxed for 1 hour
3. customto remove excess phosgene
4. temperaturecooled
5. filtrationthe amine hydrochloride was filtered off
6. customThe solvent was evaporated
7. customthe residue recrystallised from benzene-petroleum ether 1:1
8. customgiving 21.6 g, m.p. 89°-90° C.