反应详情

A mixture of the oxetane derivative of Example 2 (47.5 g., 0.053 moles), dioxane (290 ml.), water (10 ml.) and 1 g. of conc. sulfuric acid was stirred and refluxed 22 hours. The cooled reaction mixture was poured into 1.5 liters of water. A gummy solid formed which became crystalline when heated with dioxane. This product was recrystallized twice from dioxane, yielding 19.4 g. of the desired product which had a melting point of 184°-187° C.

1. temperaturerefluxed 22 hours
2. customThe cooled reaction mixture
3. customA gummy solid formed which
4. customThis product was recrystallized twice from dioxane
5. customyielding 19.4 g