Potassium Carbonate → HCID 53785237, compound

Participants

Reaction Steps

A solution of (3R,4R)-4-(3'-bromoacetonylthio)-3-phenylacetamidoazetidin-2-one (1 g., 2.7 mmole) in acetone (50 ml.) with potassium carbonate (2 g., 14.5 mmole) was stirred at 4° for 16 hours and at 22° for 4 hours. The mixture was filtered and evaporated under reduced pressure. The resulting gum was chromatographed on silica gel (10 × 4 cm.) with Analar chloroform as solvent to give a pale-yellow foam. Crystallisation from ethyl acetate gave (6R,7R)-3-keto-7-phenylacetamidocepham (0.1 g., 12.5%). M.p. I.R. and NMR in agreement with standard obtained from material prepared in Example 3.

Provenance & Evidence