HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminoquinoline → HCID 70633577, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminoquinoline | HCID 11379 | — |
| Reactant | 2-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester | HCID 78943 | — |
| Product | HCID 70633577 | HCID 70633577 | — |
Reaction Steps
Antaki, J. Am. Chem. Soc., 80, 3066-9 (1958), reports the condensation of 2-aminoquinoline and ethylethoxymethylenecyanoacetate to give ethyl 2-quinolylaminomethylenecyanoacetate which when distilled under reduced pressure afforded 1-oxo-1H-pyrimido[1,2-a]quinoline-2-carbonitrile. The compound demonstrated antischistosomal action.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04014881 |
| Source dataset | uspto-grants-1977_03 |
| ORD ID | ord-ebc842c33e3144d9952a0df6573846e5 |
| Source note | uspto-grants-1977_03 |