Hydrazine → HCID 68122226, compound

HRID 597527Notes

Reaction equation

HRID 597527 reaction equation
[F:1][C:2]1[CH:14]=[C:12]2[C:13]3[N:8]([CH:9]=[C:10]([C:16](OCC)=[O:17])[C:11]2=[O:15])[CH:7]([CH3:21])[CH2:6][CH2:5][C:4]=3[CH:3]=1.[NH2:22][NH2:23]>CO>[F:1][C:2]1[CH:14]=[C:12]2[C:13]3[N:8]([CH:9]=[C:10]([C:16]([NH:22][NH2:23])=[O:17])[C:11]2=[O:15])[CH:7]([CH3:21])[CH2:6][CH2:5][C:4]=3[CH:3]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 15518014HCID 15518014, compound

Product 1

HCID 68122226HCID 68122226, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ethyl 6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo-[ij]quinolizine-2-carboxylate (10 g., 0.0347 mole) is dissolved in methanol (200 ml.) containing 25 ml. of 97 percent hydrazine. The mixture is warmed to accelerate solution. The solution is stirred at room temperature, and solid begins to separate immediately. The solid is separated by filtration, washed with methanol and recrystallized from aqueous ethanol to provide 6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid hydrazide, m.p. 236°-238° C.

Workup

  1. additioncontaining 25 ml
  2. temperatureThe mixture is warmed
  3. customto separate immediately
  4. customThe solid is separated by filtration
  5. washwashed with methanol
  6. customrecrystallized from aqueous ethanol

Sources & evidence

ORD record
ord-5c027f857f3f4662810e363371f26a67
Source dataset
uspto-grants-1977_03
Patent number
US04014877

Reaction notes

Loading…