HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 8-Chloro-2,3,4,9-tetrahydro-1H-carbazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Cyclohexanone | HCID 7967 | — |
| Reactant | Hydrazine, (4-chlorophenyl)-, hydrochloride (1:1) | HCID 71600 | — |
| Solvent | Water | HCID 962 | — |
| Product | 8-Chloro-2,3,4,9-tetrahydro-1H-carbazole | HCID 14415821 | — |
Reaction Steps
p-Chlorophenylhydrazine hydrochloride (1.79 g., 0.010 mole) is added to a solution of 1.0 ml. (0.010 mole ) cyclohexanone and 3.0 ml. pyridine. The resulting mixture is heated under nitrogen at reflux for 4 hours, cooled to room temperature and water added to precipitate the product. After crystallization from ethanol-water 1.34 g. of the title compound was obtained, M.P. 144.0°-145.5° C. A second crop of crystals 0.18 g. is obtained from the mother liquor. Total yield, 74%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04014890 |
| Source dataset | uspto-grants-1977_03 |
| ORD ID | ord-905645f4c1f94be38baea4a266769fb3 |
| Source note | uspto-grants-1977_03 |