6-Aminopenicillanic acid → HCID 86734582, compound

Participants

Reaction Steps

In a similar manner to that of Example 17, 2-phenylbut-2-enoic acid (cis isomer) was converted into its acid chloride and coupled with (3S, 5R, 6R)-6-amino-2,2-dimethylpenam-3-carboxylic acid to give the title compound, λmax. (pH 6 phosphate buffer) 234, 345 nm (ε7,200; 4,260), νmax. (nujol) 1770 (β-lactam), τ (d6 -DMSO) values include 0.92 (d, NH), 3.83 (q, 6Hz vinylic proton), 4.3-4.5 (m, 5 and 6 H), 8.42 and 8.52 (gem dimethyl).

Provenance & Evidence