Hydrochloric Acid → 4-methoxy-5-(N-(2-morpholinoethyl)-methylsulfonamido)thiophene-2-carboxylic acid hydrochloride

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 4-methoxy-5-(N-(2-morpholinoethyl)-methylsulfonamido)-thiophene-2-carboxylate (Int. 70, 375 mg, 0.955 mmol) (prepared as described in Step 6 hereabove reported) in dioxane (8 ml), aqueous 37% HCl (3 ml) was added drop wise, and the resulting mixture was heated under MW irradiation at 100° C. for 3.5 hours. The volatiles were removed under vacuum to afford 4-methoxy-5-(N-(2-morpholinoethyl)-methylsulfonamido)thiophene-2-carboxylic acid hydrochloride (Int. 71) (383 mg, 0.955 mmol, MS/ESI+364.9 [MH]+).

Provenance & Evidence