Sodium Azide → HCID 21445477, compound

Participants

Reaction Steps

To a warm solution of 5.0 g. of 2-bromo-2'-(2-chlorobenzoyl)acetanilide in 100 ml. of methanol was added 1.8 g. of sodium azide. The solution was heated to reflux for 15 minutes. On addition of 0.77 ml. of a 35 percent solution of benzyltrimethylammonium hydroxide in methanol, and standing at room temperature overnight, 1.8 g. of pure (tlc) 3-azido-4-(2-chlorophenyl)carbostyril crystallized and was collected and washed with methanol. On recrystallization from dimethylformamide-methanol, pale yellow needles were obtained, having a melting point of 152°-155° dec.

Provenance & Evidence