Dimethyl Sulfate → HCID 21445420, compound

Participants

Reaction Steps

To a solution of 14.3 g. of 2,6-dichloro-7H-indolo[2,3-c]-quinoline in 500 ml. of tetrahydrofuran was added 2.5 g. of a 57 percent dispersion of sodium hydride in oil and 5.0 ml. of dimethylsulfate. The mixture was stirred at room temperature overnight. The initially clear solution soon deposited the product as a colorless amorphous precipitate. The solid was collected and washed with water and tetrahydrofuran. After recrystallizations from acetonitrile, 14.5 g. (98 percent) colorless fibrous needles of 2,6-dichloro-7-methylindolo[2,3-c]-quinoline were obtained, which had a melting point of 226°-227°.

Provenance & Evidence