Acetic Acid → HCID 21445640, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 35.6 g. (0.10 mole) of 3'-[2-imino-4-thiazolin-3-yl)acetanilide hydrobromide, (Example 2) 11.8 g. (0.12 mole) of potassium acetate, 150 ml. of acetic anhydride and 150 ml. of acetic acid is stirred at reflux for 1 hour. The mixture is cooled to 50° C., filtered, and the filtrate evaporated at reduced pressure. The residue is azeotroped with toluene, then triturated with 2-propanol and filtered to give 25.8 g. of crude product, which on recrystallization from aqueous acetic acid gives the product, melting point 224°-226° C. Anal. Calcd, for C15H15N3O3S: C, 56.77; H, 4.76; N, 13.24; S, 10.10. Found: C, 56.88; H, 4.77; N, 13.16; S, 9.90.

Provenance & Evidence