Fenbufen → 7-Phenyl-1-tetralone

Participants

Reaction Steps

4-(4'-Biphenylyl) butanoic acid (80g, 0.333 mole m.p. 116° C prepared by the Clemmensen reduction of 3-(4'-biphenylcarbonyl) propanoic acid) was cyclized with 85% polyphosphoric acid as described in example 8(a) to give 20.98g (30%) of the tetralone m.p. 67° C after recrystallisation from 40-60 petrol. (Found; C, 86.30; H, 6.53, C16H14O requires; C, 86.45; H, 6.35%).

Provenance & Evidence