反应详情

149 g (1 mol) of o-allyloxyphenol and 180 g (1.22 mols) if chloral are fused by gentle warming, 100 g of finely powdered sodium carbonate are added at 25° C and the mixture is subsequently stirred for 8 hours. The resulting viscous mass is stored for 5 days at room temperature and then introduced into 500 ml of water. The whole is thoroughly stirred, the water is decanted and washing is repeated three more times, with 250 ml of water at a time. The viscous oil which remains is crude 2-allyloxy-4-(1-hydroxy-2-trichloro-ethyl)-phenol. This is introduced into a solution of 250 g of potassium hydroxide in 500 ml of methanol at 30° C over the course of 2-3 hours and the reaction mixture is left to stand for 3 hours. The alkali metal salts which have precipitated are filtered off and the filtrate is evaporated under reduced pressure. The oily residue is converted into a slurry with ice water, acidified with hydrochloric acid and extracted with chloroform. The chloroform extract is washed with water, dried over sodium sulphate and then filtered through a 3 cm thick layer of Merck silica gel (0.063-0.20). After washing with chloroform, evaporation of the filtrate under reduced pressure and crystallisation of the residue from hexane yields 3-allyloxy-4-hydroxy-benzaldehyde of melting point 66°-67° C.

1. additionare added at 25° C
2. waitThe resulting viscous mass is stored for 5 days at room temperature
3. stirringThe whole is thoroughly stirred
4. customthe water is decanted
5. washwashing
6. additionThis is introduced into a solution of 250 g of potassium hydroxide in 500 ml of methanol at 30° C over the course of 2-3 hours
7. waitthe reaction mixture is left
8. waitto stand for 3 hours
9. customThe alkali metal salts which have precipitated
10. filtrationare filtered off
11. customthe filtrate is evaporated under reduced pressure
12. extractionextracted with chloroform
13. extractionThe chloroform extract
14. washis washed with water
15. dry with materialdried over sodium sulphate
16. filtrationfiltered through a 3 cm thick layer of Merck silica gel (0.063-0.20)
17. washAfter washing with chloroform, evaporation of the filtrate under reduced pressure and crystallisation of the residue from hexane