Hydrochloric Acid → 1-(3'-Acetamino-phenyl)-2-amino-propane hydrochloride

Participants

Reaction Steps

15 gm of 1-(3'-amino-phenyl)-2-amino-propane were dissolved in glacial acetic acid, and ethereal hydrochloric acid was added to the solution. The resulting solution of 1-(3'-amino-phenyl)-2-amino-propane monohydrochloride was admixed with 15 ml of acetic acid anhydride, and the mixture was stirred for 10 minutes at room temperature. Thereafter, the reaction mixture was evaporated in a water aspirator vacuum, whereupon 1-(3'-acetamino-phenyl)-2-amino-propane hydrochloride crystallized out. Recrystallized from ethanol, the product had a melting point of 181°-183° C.

Provenance & Evidence