反应详情

5.2 gm of 1-(3'-nitro-phenyl)-2-formylamino-propane was hydrogenated in methanol in the presence of Raney nickel at atmospheric pressure and room temperature. Thereafter, the catalyst was filtered off, the solvent was evaporated from the filtrate, and the residue was chromatographed on a silicagel column, using methanol/chloroform (2:8) as the flow agent. The eluate was evaporated, and the residue was recrystallized from ethyl acetate, yielding 1-(3'-aminophenyl)-2-formylamino-propane which had a melting point of 107° -108° C.

1. filtrationThereafter, the catalyst was filtered off
2. customthe solvent was evaporated from the filtrate
3. customthe residue was chromatographed on a silicagel column
4. customThe eluate was evaporated
5. customthe residue was recrystallized from ethyl acetate