反应详情

To a solution of 150 mg [cis-4-(2-phenyl-chroman-6-yloxy)-cyclohexylmethyl]amine hydrochloride (0.40 mmol) at room temperature in 4 ml of pyridine 47 μl of methanesulfonyl chloride (0.60 mmol) were added and stirring at room temperature was continued for 16 h. The reaction mixture was diluted with water and extracted with dichloromethane The combined organic layers were washed with diluted aqueous hydrochloric acid, dried with sodium sulfate and filtered, and the solvent removed under reduced pressure. The crude product was purified by reversed phase HPLC. 97 mg of the title compound were isolated as a white solid.

1. extractionextracted with dichloromethane The combined organic layers
2. washwere washed with diluted aqueous hydrochloric acid
3. dry with materialdried with sodium sulfate
4. filtrationfiltered
5. customthe solvent removed under reduced pressure
6. customThe crude product was purified by reversed phase HPLC